Effects of Flavonoid Glycoside on Mitochondrial Dysfunction and Inflammatory Oxidative Stress in Macular Degeneration

This study aimed to investigate the effects of flavonoid glycoside on mitochondrial dysfunction and inflammatory oxidative stress in macular degeneration. Sixty specific-pathogen-free male Bagg Albino mice were randomly divided into control, model glycoside. Human retinal pigment epithelium cells ARPE-19 cultured treated with dimethyl sulfoxide, sodium iodate respectively. Fundus fluorescein angiography was used detect number mouse leakage; optical coherence tomography thickness. A wave B detected by electroretinogram. Hematoxylin eosin staining observe morphology retina; phalloidin, translocase outer membrane complex subunit 20 cyclooxygenase III performed immunofluorescence. Adenosine triphosphate content each group detected. Compared control mice, leakage points increased, thickness, decreased, levels Fas FasL protein increased significantly. After treatment glycoside, decreased Flavonoid can significantly improve play a good role protecting